Causes and Detection of Bulky Adducts

Another type of DNA damage is Bulky Adducts.

Bulky DNA adducts are markers of exposure to genotoxic aromatic compounds, which reflect an individual's ability to metabolically activate carcinogens and to repair DNA damage.

For this type of damage, nucleotide excision repair (NER) will take place.

In nucleotide excision repair (NER), damaged bases are cut out within a string of nucleotides, and replaced with DNA as directed by the undamaged template strand. This repair system is used to remove pyrimidine dimers formed by UV radiation as well as nucleotides modified by bulky chemical adducts.