Single-strand DNA break

One of the types of DNA damage is “Single-strand DNA break” where only one strand of the DNA duplex is severed.

This type of DNA damage is typically corrected by Base Excision Repair (BER) pathways that correct base lesions that arise due to:-

• Oxidation.
• Alkylation.
• Deamination.
• Depurinatiation/depyrimidination damage.

Base excision repair is initiated by DNA glycosylases that hydrolytically cleave the base-deoxyribose glycosyl bond of a damaged nucleotide residue, releasing the damaged base.